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Prucalopride succinate
CAS No. 179474-85-2
Prucalopride succinate ( R-108512;R108512 )
产品货号. M12709 CAS No. 179474-85-2
Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 10MG | ￥324 | 有现货 |
|
| 25MG | ￥405 | 有现货 |
|
| 50MG | ￥551 | 有现货 |
|
| 100MG | ￥932 | 有现货 |
|
| 200MG | ￥1466 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Prucalopride succinate
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist.
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产品描述Prucalopride succinate (R-108512) is a potent, selective 5-HT4 receptor agonist with pKi of 8.6 and 8.1 for 5-HT4a and 5-HT4b, >290-fold higher affinity for 5-HT4 receptors than for other receptors; targets the impaired motility associated with chronic constipation, thus normalizing bowel movements; induces contractions (pEC50=7.48) in the guinea-pig colon, demonstrates anti-cholinergic, anticholinesterase or nonspecific inhibitory activity and does not antagonise 5-HT2A, 5-HT2B and 5-HT3 receptors or motilin, CCK1 receptors.
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同义词R-108512;R108512
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通路Endocrinology/Hormones
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靶点5-HT Receptor
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受体5-HT4A ;5-HT4B
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研究领域Other Indications
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适应症——
化学信息
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CAS Number179474-85-2
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分子量485.96
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分子式C22H32ClN3O7
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纯度>98% (HPLC)
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溶解度DMSO: ≥ 36 mg/mL
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SMILESCOCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl.C(CC(=O)O)C(=O)O
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化学全称Butanedioic acid, compd. with 4-amino-5-chloro-2,3-dihydro-N-[1-(3-methoxypropyl)-4-piperidinyl]-7-benzofurancarboxamide (1:1)
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Prins NH, et al. Br J Pharmacol. 1999 Jul;127(6):1431-7.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Bouras EP, et al. Gut. 1999 May;44(5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
2. Poen AC, et al. Aliment Pharmacol Ther. 1999 Nov;13(11):1493-7.
3. Bouras EP, et al. Gut. 1999 May;44(5):682-6.
4. Briejer MR, et al. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
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